Synthesis and evaluation of ofloxacin derivatives were carried out and evaluated for their anthelmintic activity. Synthesized ofloxacin derivatives (Compounds 1-6) were purified by using of ethanol by recrystallization procedure and characterized the molecules by analytical methods (TLC), Spectroscopic methods (FT-IR, Mass and NMR). In-silico methods were adopted for synthetic derivatives by Molinspiration online software. Determined physicochemical parameters (In-silico studies) and bioactivity scores were noted for different derivatives. Evaluated anthelmintic activity of molecules of synthesized compounds by using mebendazole as standard drug. Equal concentrations of synthesized derivatives (30/50/100 mg/ml) by using DMSO solvent. Anthelmintic activity was achieved by Earthworms (Garg’s method).
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